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Cat. No.	Product Name	Target	Signaling Pathways
T4046	BX517 PDK1 inhibitor 2,BX 517,BX-517	Akt; PDK	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	BX517 (PDK1 inhibitor 2) 是一种选择性 PDK1抑制剂，其 IC50=6 nM。
T79723	PDK-IN-2
	PDK-IN-2（Compound 1F）是一种具有IC50为68 nM的PDK抑制剂。该化合物能够抑制PDK1和PDK4在细胞内的表达，增强线粒体生物能并降低糖酵解表型，同时诱导细胞走向线粒体途径的apoptosis。此外，PDK-IN-2在4T1同基因小鼠模型中能够有效抑制肿瘤生长。
T38263	TBK1/IKKε-IN-4 TBK1/IKKε-IN-4
	TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 andHCC44 cells) treatmentdisplays selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~ 4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1].TBK1/IK...